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STEMCELL Technologies Brefeldin A

Produktkod. 17120162
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17120162 10 mg
17130162 25 mg
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Produktkod. 17120162 Leverantör STEMCELL Technologies Leverantörsnummer 73012

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Beskrivning

Protein trafficking inhibitor; Inhibits Sec7-containing guanine-exchange factor (GEF)

  • Brefeldin A is a fungal lactone antibiotic, produced by many species, including Eupenicillium brefeldianum (Klausner et al.) It reversibly interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum by indirect inhibition of ADP-ribosylation factor (ARF; Klausner et al.; Helms & Rothman; Robinson et al.; Morinaga et al.; Moss & Vaughan; Nebenführ et al.; Ktistakis et al.) Brefeldin A binds to Sec7-containing guanine-exchange factor (GEF) at the ARF-GDP-Sec7 interface, preventing the conformational change required to release GDP and activate ARF (Mossessova et al.)

Specifikationer

CAS 20350-15-6
Synonym Ascotoxin; BFA; Cyanein; Decumbin; Nectrolide; NSC 56310; NSC 89671; NSC 107456; NSC 244390; Synergisidin
Kvantitet 10 mg
Molekylformel C16H24O4
Renhet ≥98%
Produkttitel
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