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BRSK2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 11589-1-AP-150UL
Additional Details : Weight : 0.00010kg
Description
BRSK2 expressed in insect cells specifically phosphorylates WEE1A, CDC25C, and CDC25B in an in vitro assay, but a kinase-dead mutant does not. Overexpression of BRSK2 in HeLa cells results in increased phosphorylation of CDC25C. DNA damage induced by ultraviolet (UV) irradiation or methyl methane sulfonate, but not by ionizing radiation, enhances endogenous BRSK2 kinase activity in a caffeine-sensitive manner and causes translocation of BRSK2 from the cytoplasm to the nucleus. Overexpression of BRSK2 induces G2/M arrest in HeLa cells. Small interfering RNA against BRSK2 partly abrogates UV-induced G2/M arrest. BRSK2 may act as a checkpoint kinase upon DNA damage induced by UV irradiation or methyl methane sulfonate.Specifications
BRSK2 | |
Polyclonal | |
Unconjugated | |
BRSK2 | |
BR serine/threonine kinase 2, BRSK2, C11orf7, PEN11B, SAD1, STK29 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
293631, 75770, 9024 | |
-20°C | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot | |
0.18 mg/mL | |
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
D3ZML2, Q69Z98, Q8IWQ3 | |
BRSK2 | |
BRSK2 Fusion Protein Ag2195 | |
150 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |