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Eurofins DiscoverX c-Kit (V560G) Protein, Active

Produktkod. 17350624
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10 μg
250 μg
Förpackningsstorlek:
10µg
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17350624 250 μg -
17340624 10 μg 10µg
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Produktkod. 17350624 Leverantör Eurofins DiscoverX Leverantörsnummer 14730M

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Beskrivning

Active, N-terminal GST tagged recombinant human c-Kit, amino acids 544 - end, containing the V560G mutation. The V560G mutation has been found in patients with gastrointestinal stromal tumours and has been linked to poor prognosis. This mutation confers increased susceptibility to Gleevec™, for use in Kinase Assays.

Binding of stem cell factor (SCF) to C-Kit receptor tyrosine kinase induces homodimerization and intermolecular tyrosine phosphorylation of the receptor, creating docking sites for a number of SH2-containing signal transduction molecules. These include phosphatidylinositol 3'-kinase (PI 3K) and phospholipase C-1, Stat1, the Src family kinases Src, Lyn, and Fyn, and the GTPase activating protein GAP. Mutation in Kit which result in ligand-independent activation of the kinase were found to be associated with human gastrointestinal stromal tumors and mastocytosis.

GenBank X06182

Specifikationer

Formulering mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
Molekylvikt (g/mol) 76.6 kDa
Kvantitet 250 μg
Art Human
Rekombinant Recombinant
Protein Tag N-terminal GST
Uttryckssystem Recombinant enzyme expressed in Sf21 insect cells
Proteinform Truncated
Renhet eller kvalitetsklass ≥71%
Protein Kit (V560G), active
Produkttitel
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