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Caspase 12 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 55238-1-AP-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16826735

  • 1236.20 SEK / 20µL
Estimated Shipment: 08-12-2021

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Description

Description

This antibody does not cross-react with other caspases.

Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer′s disease including -gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.
Specifications

Specifications

Caspase 12
0.4 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q6UXS9
CASP 12, CASP12, CASP12P1, caspase 12 (gene/pseudogene), Caspase12, Inactive caspase 12
Rabbit
IgG
20 μL
-20°C
Primary
100506742
Immunohistochemistry (Paraffin), Immunocytochemistry, Immunofluorescence, Western Blot, Immunoprecipitation
Unconjugated
CASP12
Liquid
CASP12
Peptide
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
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