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Invitrogen™ Caspase 3 (Cleaved Asp175) Polyclonal Antibody
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Kvantitet:
100 μL
Förpackningsstorlek:
100µL
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Produktkod. 17227453 Leverantör Invitrogen™ Leverantörsnummer PA5114687
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Beskrivning

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of fragment of activated Caspase 3 resulting from cleavage adjacent to Asp175.

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
TRUSTED_SUSTAINABILITY

Specifikationer

Antigen Caspase 3 (Cleaved Asp175)
Användningsområden Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Klassificering Polyclonal
Koncentration 1 mg/mL
Konjugera Unconjugated
Formulering PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gen CASP3
Genaccessionsnr. P42574, P55213, P70677
Gene Alias A830040C14Rik; AC-3; Apopain; Casp3; CASP-3; caspase 3; Caspase 3 apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis related cysteine protease; Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis-related cysteine peptidase; caspase 3, apoptosis-related cysteine protease; Caspase-3; Caspase-3 subunit p12; Caspase-3 subunit p17; CC3; Cpp32; CPP-32; CPP32B; CPP32beta; cysteine protease CPP32; IRP; Lice; mldy; PARP cleavage protease; procaspase3; protein Yama; SCA-1; SREBP cleavage activity 1; Yama; yama protein
Gensymboler CASP3
Värd art Rabbit
Immunogen A synthesized peptide derived from human CASP3(Accession P42574), corresponding to amino acid residues C163-M182.
Reningsmetod Affinity chromatography
Kvantitet 100 μL
Regulatorisk status RUO
Primär eller sekundär Primary
Gen-ID (Entrez) 12367, 25402, 836
Målarter Human, Mouse, Rat
Innehåll och lagring -20°C
Produkttyp Antibody
Form Liquid
Isotyp IgG
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