missing translation for 'onlineSavingsMsg'
Learn More

Caspase 8 Rat anti-Human, Clone: 1H10, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9934-82

Additional Details : Weight : 0.01000kg

 View more versions of this product

Product Code. 15208257

  • 2590.00 SEK / 100µg


Estimated Shipment
25-11-2020
Add to basket

Description

Description

Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. Caspase 8 (CASP8) is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases play a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a pro-domain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. Caspase 8 is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of Caspase 8 suggests that it may interact with Fas-interacting protein FADD. Caspase 8 was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Caspase 8 binds to the death effector domain (DED) of FADD through an analogous DED domain present in tandem in the pro-form of the Caspase 8 protein. Activated Caspase 8 then activates other downstream caspases including Caspase 9, thereby committing the cell to undergo apoptosis. In addition, Caspase 8 also reacts with Jurkat cells and Tonsil. Overexpression of Caspase 8 induces apoptosis, which can be blocked by inhibitors specific for the ICE family. Many alternatively spliced transcript variants encoding different isoforms have been described for Caspase 8, however, not all variants have had their full-length sequences determined.
Specifications

Specifications

Caspase 8
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q14790
ALPS2B, CAP4, Casp-8, FLICE, FLJ17672, MACH, MCH5, MGC78473
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Western Blot
1H10
Unconjugated
CASP8
Liquid
CASP8
IgG2a
100 μg
4° C
Primary
841
Videos
Documents

For Research Use Only.