Invitrogen™ Cathelicidin Polyclonal Antibody

Beskrivning

Immunogen sequence: RSSDANLYRL LDLDPRPTMD GDPDTPKPVS FTVKETVCPR TTQQSPEDCD FKKDGLVKRC MGTVTLNQAR GSFDISCDKD NKRFALLGDF FRKSKEKIGK EFKRIVQRIK DFLRNLVPR Highest antigen sequence indentity to the following orthologs: Rat - 55%, Mouse - 54%.

Cathelicidin is an epithelial-derived antimicrobial protein found in specific granules of polymorphonuclear leukocytes of bone marrow, testis and neutrophils. Cathelicidins are one family of antimicrobial peptides characterized by conserved pro-peptide sequences that have been identified in epithelial tissues and some myeloid cells of humans and animals. LL-37/hCAP-18 is the only Cathelicidin found in humans and is expressed in inflammatory and epithelial cells. The presence of these molecules is essential for defense against invasive bacterial infection in skin. Besides their direct antimicrobial function, Cathelicidins have multiple roles in mediating innate and adaptive immunity, such as endotoxin neutralizing, angiogenesis, wound healing and promoting neutrophil chemotaxis and mast cell recruitment. Cathelicidin antimicrobial peptides qualify as prototypes of innovative drugs that may be used to treat infection and/or modulate the immune response.