Invitrogen™ CCM2 Polyclonal Antibody

Beskrivning

Immunogen sequence: GKKGKKPGIV SPFKRVFLKG EKSRDKKAHE KVTERRPLHT VVLSLPERVE PDRLLSDYIE KEVKYLGQLT SIPGYLNPSS R Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 98%.

This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.