CD101 Rat anti-Mouse, PE, Clone: Moushi101, eBioscience™
Rat Monoclonal Antibody
Brand: Affymetrix eBioscience 12-1011-80
Additional Details : Weight : 0.25000kg
DescriptionCD101 also known as V7 antigen, a member of the Ig superfamily. CD101 is a disulfide linked homodimer of unknown function. Expression of CD101 is found on monocytes, granulocytes and dendritic cells (Langerhan-like cells HLA-DR, CD1a, CD1c). In addition expression on T lymphocytes is important for cell activation. CD101+ CD28+ cells are very responsive to CD28 signaling. In combination with anti-CD28 or suboptimal levels of anti-CD3, anti-CD101 can increase proliferation thereby suggesting an activating role. The monoclonal antibody BB27 has been shown to inhibit the T cell reactivity in allogeneic and antigen-specific mixed DC-T cell cultures. Recently it has been demonstrated that mouse CD101 is found on a subpopulation of regulatory T cells (CD4, CD25, Foxp3 positive) that have high suppressor activity. Expression of CD101 on human PBMCs shows staining of about 30% of the Foxp3 positive cells. Studies have not confirmed higher suppressor activity in the human CD101 population.
|PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2|
|RP11-27K13.2, IGSF2, V7|
|4° C, store in dark, DO NOT FREEZE!|
For Research Use Only.