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CD106 (VCAM-1) Mouse anti-Rat, Clone: eBioMR106 (MR106), eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-1060-81

Additional Details : Weight : 0.01000kg

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Product Code. 15237157

  • 830.00 SEK / 50µg

Estimated Shipment
20-07-2021

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Description

Description

Description: The eBioMR106 monoclonal antibody reacts with rat CD106 (Vascular Cell Adhesion Molecule-1, VCAM-1), a 110 kDa transmembrane glycoprotein expressed by myeloid lineage and bone marrow stromal cells. Endothelial cells constitutively express low levels of CD106 and further upregulate VCAM-1 upon cytokine stimulation. CD106 binds to integrin alpha4beta1 (VLA-4, CD49d/CD29) and Integrin alpha4beta7 (LPAM-1) and these interactions in the bone marrow and thymus are important for early lymphocyte and myeloid development. Cytokine-mediated upregulation of CD106 on endothelial cells suggests a role for this antigen in the inflammatory response. Applications Reported: This eBioMR106 (MR106) antibody has been reported for use in flow cytometric analysis, immunoprecipitation, immunoblotting (WB), and immunohistology staining of frozen tissue sections. Applications Tested: This eBioMR106 (MR106) antibody has been tested by flow cytometric analysis of rat bone marrow cells. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE.

Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
Specifications

Specifications

CD106 (VCAM-1)
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P29534
CD106, DKFZp779G2333, INCAM-100, MGC99561, CD106 antigen, vascular cell adhesion protein 1
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Rat
Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
eBioMR106 (MR106)
Unconjugated
Vcam1
Liquid
Vcam1
IgG1, kappa
50 μg
4° C
Primary
25361
Videos
SDS
Documents

For Research Use Only.