missing translation for 'onlineSavingsMsg'
Learn More

CD117 (c-Kit) Mouse anti-Human, PerCP-eFluor™ 710, Clone: 104D2, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 46-1178-42

Additional Details : Weight : 0.23750kg

 View more versions of this product

Product Code. 15559176

  • 3245.00 SEK / 100 tests


Estimated Shipment
12-01-2021
Add to basket

Description

Description

00-8222) (100 µL cell sample + 100 µL IC Fixation Buffer) or 1-step Fix/Lyse Solution (cat. 00-5333) for up to 3 days in the dark at 4°C with minimal impact on brightness and FRET efficiency/compensation. Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically. Excitation: 488 nm; Emission: 710 nm; Laser: Blue Laser. Filtration: 0.2 μm post-manufacturing filtered. c-Kit, also known as CD117 and stem cell factor receptor, is a 145 kDa transmembrane tyrosine kinase encoded by the c-Kit proto-oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. c-Kit mutations correlate with tumor growth and progression in a variety of cancers including mast cell disease, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma, and lung cancer. Phosphorylation at tyrosine 703 of c-Kit allows binding of Grb2 and activation of the Ras-Raf-ERK1&2 signaling pathway.
Specifications

Specifications

CD117 (c-kit)
Monoclonal
5 μL/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
P10721
C-Kit, CD117, PBT, SCFR, mast/stem cell growth factor receptor Kit, p145 c-kit, piebald trait protein, proto-oncogene c-Kit, proto-oncogene tyrosine-protein kinase Kit, soluble KIT variant 1, tyrosine-protein kinase Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein, ckit
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
104D2
PerCP-eFluor™ 710
KIT
Liquid
KIT
IgG1, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
3815
Videos
SDS
Documents

For Research Use Only.