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CD117 (c-Kit) Rat anti-Mouse, Porcine, APC-eFluor® 780, Clone: 2B8, eBioscience™

Rat Monoclonal Antibody

758.00 SEK - 2415.00 SEK

Specifications

Antigen CD117 (c-kit)
Clone 2B8
Target Species Mouse, Porcine
Conjugate APC-eFluor® 780
Isotype IgG2b, kappa
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15351640 Affymetrix eBioscience
47-1171-80
25 μg 758.00 SEK
25µg View alternative products
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EU Stock 2
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15361640 Affymetrix eBioscience
47-1171-82
100 μg 2415.00 SEK
100µg View alternative products
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EU Stock 19
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Description

Description

Light sensitivity: This tandem is sensitive to photo-induced oxidation. Please protect this vial and stained samples from light. Fixation: Samples can be stored in IC Fixation Buffer (cat. 00-8222) (100 µL cell sample + 100 µL IC Fixation Buffer) or 1-step Fix/Lyse Solution (cat. 00-5333) for up to 3 days in the dark at 4°C with minimal impact on brightness and FRET efficiency/compensation. Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically. Excitation: 633-647 nm; Emission: 780 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered. c-Kit, also known as CD117 and stem cell factor receptor, is a 145 kDa transmembrane tyrosine kinase encoded by the c-Kit proto-oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. c-Kit mutations correlate with tumor growth and progression in a variety of cancers including mast cell disease, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma, and lung cancer. Phosphorylation at tyrosine 703 of c-Kit allows binding of Grb2 and activation of the Ras-Raf-ERK1&2 signaling pathway.
Specifications

Specifications

CD117 (c-kit)
Mouse, Porcine
IgG2b, kappa
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
2B8
APC-eFluor® 780
Flow Cytometry
Primary
Monoclonal
PBS with 0.09% sodium azide; pH 7.2
RUO

For Research Use Only.