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CD11b Mouse anti-Baboon, Chimpanzee, Cynomolgus Monkey, Human, Rhesus Monkey, Biotin, Clone: ICRF44, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 13-0118-80

Additional Details : Weight : 0.25000kg

 View more versions of this product

Product Code. 15239459

  • 710.00 SEK / 25µg

Estimated Shipment: 29-07-2021

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Description

Description

Description: The ICRF44 monoclonal antibody reacts with human CD11b, a 165 kDa adhesion molecule. CD11b associated with integrin beta2 (CD18) is expressed on the surface of monocytes, granulocytes, activated lymphocytes and a subset of NK cells. CD11b is a receptor for intercellular adhesion molecule family members CD54, CD102 and CD50 as well as for iC3b. These adhesions are crucial in cell-cell and cell-matrix interactions. Applications Reported: The ICRF44 antibody has been reported for use in flow cytometric analysis. Applications Tested: The ICRF44 antibody has been tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filtration: 0.2 μm post-manufacturing filtered.

CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3). CD11b is expressed on the surface of monocytes/macrophages, granulocytes, activated lymphocytes, a subset of NK cells, a subset of dendritic cells, and microglia in the brain. CD11b/CD18 functions as the receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X -these adhesions are critical for cell-cell and cell-matrix interactions. CD11b is expressed on 8% of spleen cells, 44% of bone marrow cells, and less than 1% of thymocytes, and is commonly used as a microglial marker in nervous tissue. The expression of CD11b increases during monocyte maturation and expression levels vary on tissue macrophages. Further, peritoneal macrophages are reported to express higher levels of CD11b than splenic macrophages. Diseases associated with CD11b dysfunction include systemic lupus erythematosus 6 and ITGAM-related susceptibility to systemic lupus erythematosus.
Specifications

Specifications

CD11b
Monoclonal
0.5 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
P11215
CD11B; CR3A; MAC-1; MAC1A; MGC117044; MO1A; SLEB6; Integrin alpha M; HCD11B
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Baboon, Chimpanzee, Cynomolgus Monkey, Human, Rhesus Monkey
Flow Cytometry
ICRF44
Biotin
ITGAM
Liquid
ITGAM
IgG1, kappa
25 μg
4° C, store in dark, DO NOT FREEZE!
Primary
101866035, 3684, 454069, 714832
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