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CD122 Mouse anti-Human, FITC, Clone: TU27, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 11-1228-41

Additional Details : Weight : 0.23750kg

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Product Code. 15516486

  • 991.00 SEK / 25 tests


Estimated Shipment date
from Supplier 26-10-2017
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Disclaimers:

For Research Use Only.


Description

Description

This TU27 monoclonal antibody reacts with human CD122, which is also known as interleukin-2 receptor beta (IL-2R beta). This receptor is expressed on NK cells, activated T cells, some B cells, monocytes, and T cell leukemias. CD122 can also be detected during early NK cell commitment. IL-2R beta associates with the IL-2R alpha (CD25) or IL-15R alpha and common gamma chain (CD132) to form the high affinity IL-2 and IL-15 receptors, respectively. By itself, this membrane receptor can bind IL-2, but with intermediate affinity. The binding of IL-2 results in internalization of the cytokine, tyrosine phosphorylation of IL-2Rβ, and activation of signaling cascades such as the JAK/STAT pathway.
Specifications

Specifications

CD122
TU27
FITC
Conjugated
Murine
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
5μL (0.5μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Interleukin-2 Receptor beta, IL-2Rb, IL-2Rp75
IgG1
RUO
Primary
Human