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CD123 Rat anti-Mouse, FITC, Clone: 5B11, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 11-1231-81

Additional Details : Weight : 0.25000kg

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Product Code. 15228179

  • 830.00 SEK / 50µg

Estimated Shipment
23-06-2021

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Description

Description

Description: The 5B11 monoclonal antibody reacts with mouse CD123, the alpha chain of the IL-3 receptor. This 60-70 kDa transmembrane protein binds to IL-3 with low affinity by itself and when associated with either CD131 (common beta chain) or AIC2A (IL-3beta) binds IL-3 with high affinity. CD123 does not transduce any intracellular signals upon binding IL-3 and requires the beta chain for this function. Applications Reported: This 5B11 antibody has been reported for use in flow cytometric analysis. Applications Tested: This 5B11 antibody has been tested by flow cytometric analysis of mouse bone marrow cell suspension. This can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser. Filtration: 0.2 μm post-manufacturing filtered.

IL-3Ra (Interleukin-3 receptor subunit alpha) belongs to the type I cytokine receptor family and is a heterodimer with a unique alpha chain paired with the common beta (beta c or CDw131) subunit. IL-3Ra is responsible for the transmission of signal of Interleukin-3. IL-3Ra and IL-3Rb chain heterodimerization is induced by Interleukin-3, which is required for receptor activation but not high affinity binding. IL-3Ra is also reported that IL-3Ra subunits are overexpressed on acute myeloid leukemia (AML) blasts compared with normal hematopoietic cells and are thus potential targets for novel therapeutic agents.
Specifications

Specifications

CD123
Monoclonal
0.5 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
P26952
CD123, CDw123, SUT-1
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry
5B11
FITC
Il3ra
Liquid
Il3ra
IgG2a, kappa
50 μg
4° C, store in dark, DO NOT FREEZE!
Primary
16188
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SDS
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For Research Use Only.