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CD152 (CTLA-4) Monoclonal Antibody (14D3), eFluor™ 660, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
1180.00 SEK - 2970.00 SEK
Specifications
Antigen | CD152 (CTLA-4) |
---|---|
Clone | 14D3 |
Concentration | 5 μL/Test |
Applications | Flow Cytometry |
Classification | Monoclonal |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15569906
|
Affymetrix eBioscience
50-1529-42 |
100 Tests |
2970.00 SEK
100 tests |
Estimated Shipment: 29-04-2024 Log in to see stock. |
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15559906
|
Affymetrix eBioscience
50-1529-41 |
25 Tests |
This item is currently unavailable or has been discontinued. View the product page for possible alternatives. |
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Description
Description: The 14D3 monoclonal antibody reacts with human CD152, also known as cytotoxic T lymphocyte antigen-4 (CTLA-4). CTLA-4, a protein with structural similarities to CD28, is expressed on activated T cells (activated B cells may also express CTLA-4) and binds the B7 family members, CD80 (B7-1) and CD86 (B7-2), with higher affinity than CD28 does. CTLA-4 and CD28 appear to deliver opposing signals to T cells: while CD28 is a potent costimulator, CTLA-4 restricts the progression of T cells to an activated state by inhibiting IL-2 secretion and cellular proliferation. The cytoplasmic portion of CTLA-4 contains ER retention motifs, resulting in intracellular localization of a large proportion of newly synthesized CTLA-4 in response to TCR signaling. The 14D3 antibody also recognizes rhesus monkey and has inhibitor activity. Applications Reported: This 14D3 antibody has been reported for use in intracellular staining followed by flow cytometric analysis. Applications Tested: This 14D3 antibody has been pre-titrated and tested by intracellular staining and flow cytometric analysis of stimulated human peripheral blood cells using the Intracellular Fixation & Permeabilization Buffer Set (cat. 88-8824) and protocol. Please refer to Best Protocols: Protocol A: Two step protocol for (cytoplasmic) intracellular proteins located under the Resources Tab online. This can be used at 5 μL (0.25 μg) per test.
CD152 (CTLA-4) Monoclonal antibody specifically detects CD152 (CTLA-4) in Human, Rhesus Monkey samples. It is validated for Flow Cytometry.Specifications
CD152 (CTLA-4) | |
5 μL/Test | |
Monoclonal | |
Liquid | |
RUO | |
P16410 | |
CTLA4 | |
Primary | |
4° C, store in dark, DO NOT FREEZE! | |
CTLA4 |
14D3 | |
Flow Cytometry | |
eFluor 660 | |
Mouse | |
Human, Rhesus Monkey | |
1493, 705673 | |
IgG2a κ | |
Affinity chromatography | |
Antibody |
For Research Use Only.