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CD154 (CD40 Ligand) Monoclonal Antibody (MR1), Biotin, eBioscience™, Invitrogen™

Armenian Hamster Monoclonal Antibody

762.00 SEK - 3005.00 SEK

Specifications

Antigen CD154 (CD40 Ligand)
Clone MR1
Concentration 0.5 mg/mL
Applications Flow Cytometry
Classification Monoclonal
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Products 3
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15239749
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Affymetrix eBioscience
13-1541-82
100 μg
1656.00 SEK
100µg
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Estimated Shipment: 07-05-2024
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15249749
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Affymetrix eBioscience
13-1541-85
500 μg
3005.00 SEK
500µg
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Estimated Shipment: 07-05-2024
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15229749
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Affymetrix eBioscience
13-1541-81
50 μg This item is currently unavailable or has been discontinued.
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Description

Description

Description: The MR1 monoclonal antibody reacts with mouse CD154, a 39 kDa transmembrane glycoprotein also known as CD40 ligand (CD40L). CD154 is expressed transiently by activated T cells. Through its binding to CD40 on antigen presenting cells (APC) including B cells, monocytes/macrophages, and dendritic cells, it serves a crucial function in T cell-APC cognate interaction. CD154-interaction with CD40 transduces signals for T-dependent B cell activation and induces B cells to enter the cell cycle. For staining for flow cytometric analysis, it is important to stimulate enriched T cells or enriched CD4 cells (using depletion strategy) prior to staining with MR1. Applications Reported: The MR1 antibody has been reported for use in flow cytometric analysis. Applications Tested: This MR1 antibody has been tested by flow cytometric analysis of stimulated mouse splenocytes. This can be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filtration: 0.2 μm post-manufacturing filtered.

CD40 Ligand (CD40-L), or CD154, is a membrane glycoprotein and differentiation antigen expressed on the surface of T cells. The CD40 Ligand stimulates B cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40 Ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL-2.
Specifications

Specifications

CD154 (CD40 Ligand)
0.5 mg/mL
Monoclonal
Liquid
RUO
P27548
IgG
Affinity chromatography
Antibody
MR1
Flow Cytometry
Biotin
Armenian Hamster
Mouse
21947
Primary
4° C, store in dark, DO NOT FREEZE!
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