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CD158a/h/g Mouse anti-Human, PE, Clone: HP-MA4, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 12-1589-42

Additional Details : Weight : 0.23750kg

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Product Code. 15506916

  • 2160.00 SEK / 100 tests


Estimated Shipment date
from Supplier 23-08-2019
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Description

Description

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several ""framework"" genes are found in all haplotypes. The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
Specifications

Specifications

CD158a/h/g
Monoclonal
5 μL/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
Q14954, Q14953, P43626
KIR2DL1, KIR2DS1, KIR2DS5
IgG2b, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
3802, 3806, 3810
Flow Cytometry
HP-MA4
PE
KIR2DS5
Liquid
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
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