CD16 Mouse, PE-eFluor 610, Clone: eBioCB16, eBioscience™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 61-0168-41
Additional Details : Weight : 0.23750kg
DescriptionThe eBioCB16 monoclonal antibody recognizes CD16 (Fc gamma RIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80kDa. CD16 is represented by two similar genes, CD16A (Fc gamma RIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (Fc gamma RIIIB), which exists as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation, and proliferation.
|Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage|
|aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|
|Low Affinity IgG Receptor 3, FCGR3a, FCGR3, IGFR5|