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CD184 (CXCR4), clone: 12G5, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9999-80

Additional Details : Weight : 0.01000kg

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Product Code. 15248327

  • 686.00 SEK / 25µg


Estimated Shipment date
from Supplier 27-03-2019
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Description

Description

Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.
Specifications

Specifications

CD184 (CXCR4)
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P61073
CXC Chemokine Receptor 4, Fusin, LESTR, HUMSTR
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry, Functional Assay, Neutralization
12G5
Unconjugated
CXCR4
Liquid
CXCR4
IgG2a, kappa
25 μg
4° C
Primary
7852
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