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CD185 (CXCR5), clone: MU5UBEE, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9185-80

Additional Details : Weight : 0.09500kg

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Product Code. 15507596

  • 850.00 SEK / 25µg


Estimated Shipment date
from Supplier 24-07-2018
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Description

Description

Description: The MU5UBEE monoclonal antibody reacts with Human CD185. CD185, which is also known as C-X-C chemokine receptor 5 (CXCR5) and Burkitt lymphoma receptor 1 (BLR1), is a seven transmembrane G protein-coupled receptor originally identified in Burkitt's lymphoma. In peripheral blood, CXCR5 is expressed on B cells, CD4+ T cells (but not Th1 or Th2 cells), as well as on a subpopulation of memory (CD45RO+) T cells. CXCR5+ circulating T cells are in a resting state and migrate to the lymph nodes due to expression of CCR7 and CD62L. In tonsil, CXCR5 is expressed on nearly all CD4+ cells along with CD45RO and such activation markers as CD69 and ICOS. Tonsillar CXCR5+ cells have been shown to induce antibody production when co-cultured with B cells, thus supporting their role in providing B cell help. Furthermore, this chemokine receptor plays a critical role in lymphocyte trafficking, in particular T cell migration into the B cell follicles of germinal centers in response to CXCL13, making CXCR5 an established marker of follicular helper T cells.Applications Reported: This MU5UBEE antibody has been reported for use in flow cytometric analysis.Applications Tested: This MU5UBEE antibody has been tested by flow cytometric analysis of human peripheral blood cells. This can be used at less than or equal to 0.25μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

CD185 (CXCR5)
Monoclonal
0.5mg/mL
PBS with 0.09% sodium azide; pH 7.2
P32302
CXC Chemokine Receptor 5, Fusin, LESTR, HUMSTR
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
HumanþNon-human PrimateþRhesus
Flow Cytometry
MU5UBEE
Unconjugated
CXCR5
Purified
CXCR5
IgG2b, kappa
25μg
Store at 2-8°C.
Primary
643
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