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CD19 Mouse anti-Human, Clone: HIB19, eBioscience™

Mouse Monoclonal Antibody

439.00 SEK - 886.00 SEK

Specifications

Antigen CD19
Clone HIB19
Target Species Human
Conjugate Unconjugated
Isotype IgG1, kappa
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15206847
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Affymetrix eBioscience
14-0199-80
25 μg
439.00 SEK
25µg
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Estimated Shipment
22-02-2021
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15216847
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Affymetrix eBioscience
14-0199-82
100 μg
886.00 SEK
100µg
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Estimated Shipment
26-01-2021
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Description

Description

Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. CD19 is a member of the immunoglobulin superfamily and has two Ig like domains. The CD19 molecule is expressed on 100% of the peripheral B cells as defined by expression of kappa or lambda light chains. CD19 appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage. Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen. The receptor for CD19 is an important functional regulator of normal and maligt B cell proliferation, and is expressed in all B cell precursor leukemias. Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. CD19 is a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. Besides being a signal-amplifying coreceptor for the B cell receptor (BCR), CD19 can also signal independently of BCR co-ligation and is a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.
Specifications

Specifications

CD19
Human
IgG1, kappa
Monoclonal
Liquid
Antibody
4° C
HIB19
Unconjugated
Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen)
Primary
Monoclonal
PBS with 0.09% sodium azide; pH 7.2
RUO
SDS

For Research Use Only.