CD193 (CCR3), APC, clone: eBio5E8-G9-B4 (5E8-G9-B4), eBioscience™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 17-1939-41
Additional Details : Weight : 0.23750kg
DescriptionDescription: The eBio5E8-G9-B4 monoclonal antibody reacts with human CD193 (CCR3, CKR3). CD193 is a member of the seven transmembrane G-protein coupled receptor (GPCR) family, and is a high affinity chemokine receptor for the chemokines eotaxin-1 (CCL11), eotaxin-2 (CCL24), eotaxin-3 (CCL26) and MCP-4 (CCL13), but has also been reported to bind RANTES, MCP-3 and MCP-4. CD193 is highly expressed on the surface of eosinophils, and is the key eosinophil chemokine receptor responsible for the regulation of eosinophil migration and function. In addition to eosinophils, CD193 is also expressed on CD4+ TH2 cells, basophils, mast cells, mononuclear phagocytes, platelets, CD34+ hematopoietic progenitors and airway epithelial cells. CD193 likely plays an important role in the migration of eosinophils in allergic airway inflammation and asthma. CD193 can also serve as a receptor for HIV-1 cell entry.Applications Reported: This eBio5E8-G9-B4 (5E8-G9-B4) antibody has been reported for use in flow cytometric analysis.Applications Tested: This eBio5E8-G9-B4 (5E8-G9-B4) antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood. This can be used at 5 μL (0.25 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser.Filtration: 0.2μm post-manufacturing filtered.
|PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2|
|b-chemokine receptor, C-C chemokine receptor type 3, C-C CKR-3, CC chemokine receptor 3, CC-CKR-3, CCR-3, chemokine (C-C motif) receptor 3, chemokine (C-C) receptor 1,-like 2, chemokine (C-C) receptor 3, CKR3, CMKBR3, eosinophil CC chemokine receptor 3, eosinophil eotaxin receptor, macrophage inflammatory protein 1-alpha receptor-like 2, MGC102841, MIP-1 alpha RL2, MIP-1 alphaRL2, probable C-C chemokine receptor type 3|
|IgG2b, kappa, kappa|
|Store at 2-8°C. Do not freeze. Light-sensitive material.|
For Research Use Only.