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CD195 (CCR5) Mouse anti-Human, APC, Clone: NP-6G4, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 17-1956-42

Additional Details : Weight : 0.23750kg

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Product Code. 15558046

  • 2420.00 SEK / 100 tests


Estimated Shipment
15-01-2021
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Description

Description

Human immunodeficiency virus (HIV) and related virus require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains fusion and entry of human white blood cells. CCR5 is required for the infection by HIV-1, HIV-2, and SIV. The beta-chemokines RANTES, MIP-alpha and MIP-beta are the ligands for CCR5 and prevent infection by M-tropic HIV-1. CXC5 associates with the surface CD4-gp120 of HIV complex and leads to membrane fusion and virus entry of target cells. The amino-terminal domain and the extracellular loops of CCR5 serve as HIV biding sites. CCR5 messenger RNA is expressed in lymphoid organs and monocytes.
Specifications

Specifications

CD195 (CCR5)
Monoclonal
5 μL/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
P51681
C-C CKR-5, CC-CKR-5, HIV-1 fusion coreceptor, CHEMR13, CD195 antigen, CMKBR5
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
NP-6G4
APC
CCR5
Liquid
CCR5
IgG1, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
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For Research Use Only.