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CD197 (CCR7) Rat anti-Human, PE-Cy7, Clone: 3D12, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 25-1979-42

Additional Details : Weight : 0.23750kg

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Product Code. 15508516

  • 2955.00 SEK / 100 tests


EU Stock 3
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Disclaimers:

For Research Use Only.


Description

Description

The 3D12 monoclonal antibody reacts with human CCR7, also known as EBI-1 and CD197. CCR7 is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains and functions as a receptor for 6Ckine/SLC (secondary lymphoid-tissue chemokine), CCL19 and CCL21. CCR7 has been shown to be internalized via clathrin-coated pits and the majority recycled back to the plasma membrane. CCR7 is expressed on T cells and can be used to distinguish populations of naïve from central and effector memory T cells. CCR7 has been shown to play a role in migration of memory T cells to inflamed tissue. Expression of CCR7 is also found on DC’s. During DC maturation CCR7 expression increases and is thought to be involved in a variety of functions: chemotaxis to the lymph node, cellular architecture, rate of endocytosis, survival and maturation. Expression of CCR7 on the cell surface can be down regulated upon ligand binding.
Specifications

Specifications

CD197 (CCR7)
3D12
PE-Cy7
Conjugated
Rat
100 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Monoclonal
Flow Cytometry
5μL (0.25μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
C-C chemokine receptor type 7, EBI-1, MIP-3 beta Receptor
IgG2a
RUO
Primary
Human