missing translation for 'onlineSavingsMsg'
Learn More

CD2 Rat anti-Mouse, Functional Grade, Clone: RM2-5, eBioscience™

Rat Monoclonal Antibody

808.00 SEK - 2600.00 SEK

Specifications

Antigen CD2
Clone RM2-5
Target Species Mouse
Conjugate Functional Grade
Isotype IgG2b, lambda
View More Specs

Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15288327
View Documents
Affymetrix eBioscience
16-0021-81
50 μg
808.00 SEK
50µg
View alternative products
Save Up to 
»
Estimated Shipment
13-01-2021
Add to basket
 
15208337
View Documents
Affymetrix eBioscience
16-0021-85
500 μg
2600.00 SEK
500µg
View alternative products
Save Up to 
»
Estimated Shipment
13-01-2021
Add to basket
 
Description

Description

Aggregation: Less than 10%, as determined by HPLC. CD2 (LFA-2) is a monomeric surface antigen (MW range 45-58 kDa) of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells. CD2 is one of the earliest T-cell markers, being present on more than 95% of thymocytes and it is also found on some natural killer cells, but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it. The interaction betwee CD2 and CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection. Diseases associated with CD2 dysfunction include penis squamous cell carcinoma and immune deficiency due to the absence of the thymus.
Specifications

Specifications

CD2
Mouse
IgG2b, lambda
Monoclonal
Liquid
Antibody
4° C
RM2-5
Functional Grade
Flow Cytometry, Functional Assay, Neutralization
Primary
Monoclonal
PBS with no preservative; pH 7.2
RUO
SDS

For Research Use Only.