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CD200 Receptor, clone: OX108, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9201-82

Additional Details : Weight : 0.01000kg

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Product Code. 15268157

  • 934.00 SEK / 100µg


Estimated Shipment date
from Supplier 24-09-2018
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Description

Description

Description: The monoclonal antibody OX108 recognizes human CD200R also known as OX2. CD200R is an inhibitory receptor with a similar structure as its ligand, CD200, yet lacks an ITIM domain typically found in inhibitory receptors. Instead the CD200R cytoplasmic domain contains a novel phosphotyrosine binding domain, NPXY, which after binding SHIP inhibits ERK, JNK and MAPK p38 pathways. In activated macrophages signaling results in inhibition of TNFalpha secretion. Isoforms of CD200R have been identified and are thought to play a major role in differentiation, especially in regards to tolerogenic DCs. Expression is restricted to hematopoietic cells: myeloid cells (monocytes, macrophages, DCs, neutrophils, mast cells and basophils) and a subset of T lymphocytes as well as langerhans (LC) cells and dendritic epidermal T cells. The epitope of OX108 is thought to be near the binding site of CD200.Applications Reported: This OX108 antibody has been reported for use in flow cytometric analysis.Applications Tested: This OX108 antibody has been tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

CD200 Receptor
Monoclonal
0.5mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q8TD46
CD200R, HCRTR2, MOX2R, OX2R, CD200R1
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
OX108
Unconjugated
CD200R1
Liquid
CD200R1
IgG1, kappa
100μg
4° C
Primary
131450
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