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CD200R3 Rat anti-Mouse, Alexa Fluor 647, Clone: Ba13, Invitrogen™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 51-2001-82

Additional Details : Weight : 0.01000kg

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Product Code. 16606394

  • 3480.00 SEK / Each
Estimated Shipment: 29-08-2022
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Description

Description

Description: This Ba13 monoclonal antibody recognizes mouse CD200R3, a surface receptor expressed by basophils and mast cells. Applications Reported: This Ba13 antibody has been reported for use in flow cytometric analysis. Applications Tested: This Ba13 antibody has been tested by flow cytometric analysis of MC/9 cell line. This may be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 633-647 nm; Emission: 668 nm; Laser: Red Laser.

CD200R3 is a dimeric cell surface receptor also known as CD200RLb. CD200R3 contains two Ig-like extracellular domains and as such is a member of the immunoglobulin superfamily of receptors. The intracellular region of CD200R3 associates with the adaptor molecule DAP12, and possibly also DAP10, CD3 zeta and FcR gamma-chain, indicating that it is capable of transducing stimulatory signals. In this respect CD200R3 bears similarity to activatory receptors CD200R2 and CD200R4. In contrast, an inhibitory receptor CD200R (also known as CD200R1) relies on other adaptors. CD200R3 is primarily expressed by basophils and mast cells, cells known to be involved in anti-parasitic immune responses and frequently also allergic reactions. The surface expression of CD200R3 decreases when basophils are activated by ligating their CD16 and CD32. Remarkably, most of this downregulation is observed within the first 30 minutes after activation. Unlike CD200R, CD200R3 does not bind CD200.
Specifications

Specifications

CD200R3
Monoclonal
0.2 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q5UKY4
CD200R3
Mouse primary basophils
100 μg
Primary
Mouse
Antibody
IgG2a κ
Flow Cytometry
Ba13
Alexa Fluor 647
CD200R3
4733401I18Rik; 4833409J19Rik; AI505817; BB106877; CD200 cell surface glycoprotein receptor 3; CD200 cell surface glycoprotein receptor-like 3; CD200 cell surface glycoprotein receptor-like b; CD200 receptor 3; CD200 receptor-like 3; Cd200r3; Cd200rlb; Cell surface glycoprotein CD200 receptor 3; Cell surface glycoprotein OX2 receptor 3; mCD200RLb
Rat
Affinity chromatography
RUO
74603
4°C, store in dark, DO NOT FREEZE!
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