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CD202b (TIE2) Monoclonal Antibody (TEK4), Functional Grade, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

2470.00 SEK - 3775.00 SEK

Specifications

Antigen CD202b (TIE2)
Clone TEK4
Concentration 1 mg/mL
Classification Monoclonal
Conjugate Functional Grade
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Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15258727
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Affymetrix eBioscience
16-5987-82
100 μg
2470.00 SEK
100µg
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15268727
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Affymetrix eBioscience
16-5987-85
500 μg This item is currently unavailable or has been discontinued.
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Description

Description

Description: The TEK4 monoclonal antibody reacts with mouse Tie-2, also known as CD202. A member of the tyrosine kinase receptor family, Tie-2 is expressed on endothelial and a subset of hematopoietic cells and is believed to play a role in both angiogenesis and hematopoiesis during development of the mouse embryo. In fetal liver and adult bone marrow, Tie-2 is expressed by a subpopulation of hematopoietic progenitor cells characterized as Lineage markers^-, c-Kit^+, Sca1^+ cells. Long-term multilineage repopulating cells were detected in Tie-2^+, Lineage^-, c-Kit^+, Sca1^+ cells but not in Tie-2^-, Lineage^-, c-Kit^+, Sca1^+ cells. Applications Reported: The TEK4 antibody has been reported for use in flow cytometric analysis. Applications Tested: The TEK4 antibody has been tested by blocking of staining with fluorochrome conjugated TEK4 on mouse bone marrow cells. This can be used at less than or equal to 1 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Endotoxin: Less than 0.001 ng/ug antibody as determined by the LAL assay. Storage and handling: Use in a sterile environment. Filtration: 0.

The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells. TEK signaling appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis, and defects in TEK are associated with inherited venous malformations. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Immunoblotting showed that TIE2 expression was increased by thyroid-stimulating hormone and agents that increased intracellular cAMP. HSCs expressing the receptor tyrosine kinase TIE2 are quiescent and antiapoptotic and comprise a side population of HSCs that adhere to osteoblasts in the bone marrow niche.
Specifications

Specifications

CD202b (TIE2)
1 mg/mL
Functional Grade
Rat
Mouse
Q02858
IgG1 κ
Affinity chromatography
Antibody
TEK4
Monoclonal
Liquid
RUO
PBS with no preservative; pH 7.2
21687
Primary
4° C
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