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CD209 (DC-SIGN) Rat anti-Mouse, PE, Clone: LWC06, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 12-2092-80

Additional Details : Weight : 0.25000kg

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Product Code. 15218729

  • 982.00 SEK / 25µg


Estimated Shipment date
from Supplier 27-03-2020
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Description

Description

Applications Tested: This LWC06 antibody has been tested by flow cytometric analysis of mouse CIRE/DC-SIGN-transfected CHO cells. This can be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 μm post-manufacturing filtered. This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.
Specifications

Specifications

CD209 (DC-SIGN)
Monoclonal
0.2 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
Q91ZX1
CD209, CDSIGN, CIRE, DC-SIGN, DC-SIGN1, Dcsign, MGC130443, SIGN-R1, SIGNR5, CD209a
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry
LWC06
PE
Cd209a
Liquid
Cd209a
IgG2a, kappa
25 μg
4° C, store in dark, DO NOT FREEZE!
Primary
170786
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