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CD221 (IGF1R) Mouse anti-Human, Alexa Fluor® 488, Clone: 1H7, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 53-8849-42

Additional Details : Weight : 0.23750kg

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Product Code. 15500267

  • 2265.00 SEK / 100 tests


EU Stock 1
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Description

Description

Insulin growth factor 1 receptor belongs to the family of tyrosine receptor kinases. It is involved in activation of various substrates including IGF and neurotensin, regulation of metabolism, cell division, maintece, and inflammation response. The protein is a tetramer consisting of two alpha, and two beta subunits. The alpha-subunits binds to insulin growth factor 1 with higher affinity than to insulin growth factor 2. Binding results in a conformational change, followed by autophosphorylation of IGF-1R at positions 1134, 1135, 1136. The activated IGF-1R in turn, causes phosphorylation of substrate proteins, followed by sequential activation of RAS, RAF, and mitogen-activated protein kinase isoforms ERK, p38, and JNK, leading to the transcription of genes that drive proliferation. This antibody recognizes the beta-subunit of IGF-1R.
Specifications

Specifications

CD221 (IGF1R)
Monoclonal
5 μL/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
P08069
IGF1R
IgG1, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
3480
Flow Cytometry
1H7
Alexa Fluor® 488
IGF1R
Liquid
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
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