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CD226 (DNAM-1) Monoclonal Antibody (10E5), Functional Grade, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

1654.00 SEK - 4340.00 SEK

Specifications

Antigen CD226 (DNAM-1)
Clone 10E5
Concentration 1 mg/mL
Applications Flow Cytometry, Functional Assay
Classification Monoclonal
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15258597
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Affymetrix eBioscience
16-2261-81
50 μg
1654.00 SEK
50µg
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Estimated Shipment: 07-05-2024
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15268597
View Documents Promotion Details
Affymetrix eBioscience
16-2261-85
500 μg
4340.00 SEK
500µg
View alternative products
Save Up to 
»
Estimated Shipment: 07-05-2024
to see stock.
Please to purchase this item. Need a web account? Register with us today!
Description

Description

Description: This 10E5 monoclonal antibody reacts with mouse CD226, which is also known as DNAX accessory molecule-1 (DNAM-1). CD226 is an adhesion molecule expressed primarily on T cells, including thymocytes. The highest levels of CD226 are found on naive CD8 T cells. Moreover, expression of CD226 is regulated differentially in CD4 T cells. Under certain culture conditions, CD226 can be upregulated in Th1 and downregulated in Th2 and Th0 cells. This cell surface receptor can also be detected on natural killer cells, some B cell subsets, monocytes, and platelets. Interaction with its ligands, the poliovirus receptor (CD155) and CD112, results in adhesion and cell signaling events that promote innate and adaptive immunity, including differentiation, survival, and cytotoxicity. The 10E5 monoclonal antibody has been reported to inhibit antigen-specific T cell proliferation and IFN-gamma production in vivo. Applications Reported: This 10E5 antibody has been reported for use in flow cytometric analysis and functional assays. Applications Tested: This 10E5 antibody has been tested by flow cytometric analysis of 3-day CD3/CD28-stimulated mouse splenocytes. This can be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.

DNAM 1 is a receptor expressed by peripheral blood T lymphocytes that is involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T lymphocytes. DNAM 1 is broadly expressed on T cells, NK cells, platelets, monocytes and a subset of B cells. DNAM-1 is also expressed by a subset of CD3 positive thymocytes.
Specifications

Specifications

CD226 (DNAM-1)
1 mg/mL
Monoclonal
Liquid
RUO
PBS with no preservative; pH 7.2
adhesion glycoprotein; BC051526; Cd226; CD226 antigen; CD226 molecule; DNAM 1; DNAM1; DNAM-1; DNAX accessory molecule 1; DNAX accessory molecule-1; platelet and T cell activation antigen 1; platelet and T-cell activation antigen 1; Pta1; T lineage-specific activation antigen 1 antigen; TLiSA1
Cd226
Primary
4° C
Cd226
10E5
Flow Cytometry, Functional Assay
Functional Grade
Rat
Mouse
Q8K4F0
225825
IgG2b κ
Affinity chromatography
Antibody
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