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CD244 Mouse anti-Human, Clone: eBioPP35 (PP35), eBioscience™

Mouse Monoclonal Antibody

534.00 SEK - 978.00 SEK

Specifications

Antigen CD244
Clone eBioPP35 (PP35)
Target Species Human
Conjugate Unconjugated
Isotype IgG1
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15227327
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Affymetrix eBioscience
14-2449-80
25 μg
534.00 SEK
25µg
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Estimated Shipment
14-01-2021
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15237327
View Documents
Affymetrix eBioscience
14-2449-82
100 μg
978.00 SEK
100µg
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Save Up to 
»
Estimated Shipment
14-01-2021
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Description

Description

CD244 (2B4, SLAMF4) is a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via CD244 is thought to modulate NK-cell cytolytic activity. CD244 interacts with SLAMF2, causing the activation of both SLAMF4- and SLAMF2-expressing cells. Patients with systemic lupus erythmatosus have lower than normal levels of SLAMF4 expressed on their NK cells and monocytes, suggesting that SLAMF4 may play a role in the pathology of this autoimmune disease. Diseases associated with CD244 dysfunction include rheumatoid arthritis and lymphoproliferative syndrome. Alternatively spliced transcript variants encoding different isoforms of CD244 have been found for this gene.
Specifications

Specifications

CD244
Human
IgG1
Monoclonal
Liquid
Antibody
4° C
eBioPP35 (PP35)
Unconjugated
Flow Cytometry, Immunoprecipitation, Western Blot
Primary
Monoclonal
PBS with 0.09% sodium azide; pH 7.2
RUO
SDS

For Research Use Only.