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CD25 Monoclonal Antibody (PC61.5), Biotin, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

624.00 SEK - 4085.00 SEK

Specifications

Antigen CD25
Clone PC61.5
Concentration 0.5 mg/mL
Applications Flow Cytometry
Classification Monoclonal
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Products 4
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15269499
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Affymetrix eBioscience
13-0251-82
100 μg
1222.00 SEK
100µg
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15279499
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Affymetrix eBioscience
13-0251-85
500 μg
2450.00 SEK
500µg
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Estimated Shipment: 10-04-2024
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15289499
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Affymetrix eBioscience
13-0251-86
1 mg
4085.00 SEK
1mg
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Estimated Shipment: 08-05-2024
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15259499
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Affymetrix eBioscience
13-0251-81
50 μg This item is currently unavailable or has been discontinued.
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Description

Description

Description: The PC61.5 antibody reacts with mouse CD25, the 55 kDa interleukin-2 receptor alpha chain (IL-2R alpha). CD25 is expressed by early progenitors of the T and B lineage as well as by activated mature T and B lymphocytes. By itself, CD25 binds IL-2 only with low affinity. However, CD25 associates with CD122 (IL-2 receptor beta chain) and CD132 (common gamma chain) to form the high affinity IL-2 receptor. Binding of IL-2 to both the high and low affinity classes of IL-2 receptor is inhibited by the PC61.5 antibody. CD25 plays a role in lymphocyte differentiation and activation/proliferation. Applications Reported: The PC61.5 antibody has been reported for use in flow cytometric analysis. Applications Tested: The PC61.5 antibody has been tested by flow cytometric analysis of mouse splenocytes and Con A-stimulated splenocytes. This can be used at less than or equal to 0.125 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filtration: 0.2 μm post-manufacturing filtered.

CD25 (IL2 receptor alpha chain/IL2RA) is a cytokine that plays a role in the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2RA) is a heterotrimeric protein complex with a gamma chain also shared by interleukin 4 (IL4) and interleukin 7 (IL7). IL2RA, IL2R beta chain (IL2RB), and the IL2R gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric IL2RA chains result in low-affinity receptor, while homodimeric IL2RB chains produce a medium-affinity receptor. The expression of IL2 in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. IL2 is primarily produced by mature T cells. IL2 plays an important role as a growth factor, differentiation factor, and regulator of cell death. IL-2 stimulates the proliferation of B cells, augments natural killer cell activity, and inhibits granulocyte macrophage colony formation. The targeted disruption of a similar gene in mice leads to μgcerative colitis-like disease, which suggests a role in the immune response to antigenic stimuli. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
Specifications

Specifications

CD25
0.5 mg/mL
Monoclonal
Liquid
RUO
P01590
IgG1 λ
Affinity chromatography
Antibody
PC61.5
Flow Cytometry
Biotin
Rat
Mouse
16184
Primary
4° C, store in dark, DO NOT FREEZE!
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