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CD254 (RANK Ligand) Mouse anti-Human, Clone: MIH24, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-6619-82

Additional Details : Weight : 0.01000kg

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Product Code. 15237927

  • 2265.00 SEK / 100µg


Estimated Shipment date
from Supplier 22-07-2019
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Description

Description

2 μm post- manufacturing filtered. This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregcy. Two alternatively spliced transcript variants have been found.
Specifications

Specifications

CD254 (RANK Ligand)
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
O14788
RP11-86N24.2, CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf, TNF-related activation-induced cytokine, TNFSF11, TRANCE
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
ELISA, Flow Cytometry
MIH24
Unconjugated
TNFSF11
Liquid
TNFSF11
IgG2b, kappa
100 μg
4° C
Primary
8600
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