CD254 (RANK Ligand) Rat anti-Mouse, Biotin, Clone: IK22/5, eBioscience™
Rat Monoclonal Antibody
Brand: Affymetrix eBioscience 13-5952-82
Additional Details : Weight : 0.25000kg
DescriptionThis gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregcy. Two alternatively spliced transcript variants have been found.
|CD254 (RANK Ligand)|
|PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2|
|RP11-86N24.2, CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf, TNF-related activation-induced cytokine, TNFSF11, TRANCE|
|4° C, store in dark, DO NOT FREEZE!|
For Research Use Only.