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CD262 (DR5) Mouse anti-Human, Clone: DJR2-2 (2-6), eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9909-80

Additional Details : Weight : 0.01000kg

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Product Code. 15268227

  • 858.00 SEK / 25µg


Estimated Shipment date
from Supplier 24-04-2019
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Description

Description

DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a recently identified death domain containing receptor for TRAIL, which mediates TRAIL induced apoptosis. DR5 is a member of the TNF-receptor superfamily, and contains an intracellular death domain. DR5 can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by DR5. Two transcript variants encoding different isoforms of DR5 and one non-coding transcript have been found. Overexpression of DR5 induces apoptosis and activates NF-kappa-B. DR5 is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. Diseases associated with DR5 dysfunction include squamous cell carcinoma, and diffuse infiltrative lymphocytosis syndrome.
Specifications

Specifications

CD262 (DR5)
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
O14763
CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9, Trail receptor 2
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry, Western Blot
DJR2-2 (2-6)
Unconjugated
TNFRSF10B
Liquid
TNFRSF10B
IgG1, kappa
25 μg
4° C
Primary
8795
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