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CD265 (RANK) Rat anti-Mouse, Clone: R12-31, eBioscience™

Rat Monoclonal Antibody

1006.00 SEK - 3125.00 SEK

Specifications

Antigen CD265 (RANK)
Clone R12-31
Target Species Mouse
Conjugate Unconjugated
Isotype IgG2a, kappa
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Products 3
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15297917
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Affymetrix eBioscience
14-6612-81
50 μg
1006.00 SEK
50µg
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Estimated Shipment
31-05-2021
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15207927
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Affymetrix eBioscience
14-6612-82
100 μg
1762.00 SEK
100µg
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Estimated Shipment
31-05-2021
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15217927
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Affymetrix eBioscience
14-6612-85
500 μg
3125.00 SEK
500µg
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Estimated Shipment
31-05-2021
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Description

Description

Description: The R12-31 monoclonal antibody reacts with mouse RANK (Receptor activator of NF-kappaB), a recently cloned member of the TNFR superfamily with no significant homology to other members of this family. RANK ligand (RANKL/TRANCE/ OPGL) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival. The cytoplasmic domain of RANK interacts with TRAF2, TRAF5 and TRAF6. Overexpression of RANK activates NF-kappaB and c-Jun-terminal kinase (JNK) pathways. Recent studies have shown that RANK interaction with TRAF6 activates NF-kappaB, whereas JNK activation is mediated through binding of RANK to TRAF2. Applications Reported: The R12-31 antibody has been reported for use in flow cytometric analysis. Applications Tested: The R12-31 antibody has been tested by flow cytometric analysis of mouse RANK transfected cells. This can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered.

RANK is a member of the tumor necrosis factor receptor (TNFR) family. The full length mouse RANK cDNA encodes a type I transmembrane protein with an extracellular and a cytoplasmic domain. The extracellular domain contains two potential N-linked glycosylation sites. RANK shares significant amino acid homology with other members of the TNFR family in its extracellular four cysteine-rich repeats. Human and murine RANK share 81% amino acid identity in their extracellular domains.
Specifications

Specifications

CD265 (RANK)
Mouse
IgG2a, kappa
Monoclonal
Liquid
Antibody
4° C
R12-31
Unconjugated
Flow Cytometry
Primary
Monoclonal
PBS with 0.09% sodium azide; pH 7.2
RUO
SDS

For Research Use Only.