CD272 (BTLA) Mouse anti-Mouse, Biotin, Clone: 8F4, eBioscience™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 13-5956-80
Additional Details : Weight : 0.25000kg
Description2 μm post- manufacturing filtered. B and T lymphocyte attenuator (BTLA) is a 289 amino acid recently identified inhibitory receptor that provides crucial activating or attenuating signals for T cells. It is a third member of co-inhibitory receptors of the CD28 immunoglobulin superfamily with similarities to (CTLA)-4 and (PD)-1 and interacts with a B7 homolog, B7H4. BTLA is constitutively expressed on most CD4+ and CD8+ T cells and its expression progressively decreases upon T cell activation. It remains expressed on Th1 cells but not Th2 cells. BTLA is a unique co-receptor which interacts with the tumor necrosis factor receptor superfamily member herpesvirus entry mediator (HVEM) and this interaction is an important pathway regulating lymphocyte activation and/or homeostasis in the immune response and might also play an important role in the maintece of T cell tolerance.
|PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2|
|B and T lymphocyte attenuator; B- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein; BTLA1; CD272|
|4° C, store in dark, DO NOT FREEZE!|
For Research Use Only.