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CD273 (B7-DC), Biotin, clone: MIH18, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 13-5888-82

Additional Details : Weight : 0.25000kg

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Product Code. 15269899

  • 1708.00 SEK / 100µg


Estimated Shipment date
from Supplier 27-08-2018
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Description

Description

Description: The MIH18 monoclonal antibody reacts with human B7-DC, also known as PD-L2. B7-DC, a recently identified member of the B7 family, has a predicted molecular weight of approximately 25kDa and belongs to the Ig superfamily. B7-DC is primarily expressed by subpopulations of dendritic cells and monocytes/macrophages. Although B7-DC has structural and sequence similarities to the B7 family, it does not bind CD28/CTLA-4, rather it is a ligand for PD-1. The interactions between PD-1 and B7-DC/PD-L2 have been reported to be involved in costimulation or suppression of T cell proliferation depending on state of cellular activation. MIH18 is a useful tool for studies to elucidate the exact function of B7-DC/PD-L2 in APC/T cell interaction and to characterize the expression pattern of this molecule in humans. MIH18 is a blocking antibody.Applications Reported: The MIH18 antibody has been reported for use in flow cytometric analysis.Applications Tested: The MIH18 antibody has been tested by flow cytometric analysis of mature dendritic cells and normal human peripheral blood cells. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

CD273 (B7-DC)
Monoclonal
0.5mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
Q9BQ51
B7-DC, Btdc, F730015O22Rik, MGC124039, MGC124040, PD-L2
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
MIH18
Biotin
PDCD1LG2
Conjugated
PDCD1LG2
IgG1, kappa
100μg
Store at 2-8°C. Do not freeze.
Primary
80380
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