CD273 (B7-DC) Rat anti-Mouse, Functional Grade, Clone: TY25, eBioscience™
Rat Monoclonal Antibody
Brand: Affymetrix eBioscience 16-5986-81
Additional Details : Weight : 0.01000kg
DescriptionEndotoxin: Less than 0.001 ng/ug antibody as determined by the LAL assay. Storage and handling: Use in a sterile environment. Filtration: 0.2 μm post-manufacturing filtered. Purity: Greater than 90%, as determined by SDS-PAGE. Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay. Aggregation: Less than 10%, as determined by HPLC. Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by co gnate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2, both of which are thought act as a negative regulator of T cell activation. However, it has been suggested that PDL-2 can act to stimulate an immunogenic response through and alternative receptor from PD-1. At least three isoforms of PDL-2 are known to exist; this antibody is specific to the largest isoform. PDL-2 antibody has no cross-reactivity to PDL-2.
|PBS with no preservative; pH 7.2|
|B7-DC, Btdc, F730015O22Rik, MGC124039, MGC124040, PD-L2|
|Flow Cytometry, Functional Assay, Neutralization|
For Research Use Only.