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  6. Invitrogen™ CD274 (PD-L1, B7-H1) Monoclonal Antibody (MIH5), Biotin, eBioscience™, Invitrogen™

Invitrogen™ CD274 (PD-L1, B7-H1) Monoclonal Antibody (MIH5), Biotin, eBioscience™, Invitrogen™

Produktkod. 15289969
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Produktkod. 15289969 Leverantör Invitrogen™ Leverantörsnummer 13598281

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Beskrivning

Rat Monoclonal Antibody

Description: The MIH5 monoclonal antibody reacts with mouse B7-H1, also known as PD-L1. B7-H1, a member of the B7 family, has a predicted molecular weight of approximately 40 kDa and belongs to the Ig superfamily. B7-H1 is expressed on a majority of leukocytes including T, B, NK and DC. B7-H1 is a ligand for PD-1. Interaction of PD-1 with either PD-L1 (B7-H1) or PD-L2 (B7-DC) results in inhibition of T and B cell responses. MIH5 is reported to be a blocking antibody. Applications Reported: The MIH5 antibody has been reported for use in flow cytometric analysis. Applications Tested: The MIH5 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filtration: 0.2 μm post-manufacturing filtered.

Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. To date, one specific receptor has been identified that can be ligated by PD-L1. This receptor, programmed death receptor 1 (PD-1), has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production. PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion.
TRUSTED_SUSTAINABILITY

Specifikationer

Antigen CD274 (PD-L1, B7-H1)
Användningsområden Flow Cytometry
Klassificering Monoclonal
Klona MIH5
Koncentration 0.5 mg/mL
Konjugera Biotin
Formulering PBS with 0.09% sodium azide; pH 7.2
Gen Cd274
Genaccessionsnr. Q9EP73
Gene Alias A530045L16Rik; B7 homolog 1; B7-H; B7h1; B7-H1; Cd274; CD274 antigen; CD274 molecule; PDCD1 ligand 1; Pdcd1l1; Pdcd1lg1; Pdl1; PD-L1; pdl-1; Programmed cell death 1 ligand 1; programmed death ligand 1; RGD1566211; sCD274; soluble CD274; soluble PD L1; sPD L1
Gensymboler Cd274
Värd art Rat
Reningsmetod Affinity chromatography
Kvantitet 50 μg
Regulatorisk status RUO
Primär eller sekundär Primary
Gen-ID (Entrez) 60533
Målarter Mouse
Innehåll och lagring 4°C, store in dark, DO NOT FREEZE!
Produkttyp Antibody
Form Liquid
Isotyp IgG2a λ
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For Research Use Only.

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