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CD275 (B7-H2) Monoclonal Antibody (HK5.3), Biotin, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
1016.00 SEK - 2320.00 SEK
Specifications
Antigen | CD275 (B7-H2) |
---|---|
Clone | HK5.3 |
Concentration | 0.5 mg/mL |
Applications | Flow Cytometry |
Classification | Monoclonal |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15239979
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Affymetrix eBioscience
13-5985-82 |
100 μg |
2320.00 SEK
100µg |
Estimated Shipment: 07-05-2024 Log in to see stock. |
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13485289
|
Affymetrix eBioscience
13-5985-81 |
50 μg |
This item is currently unavailable or has been discontinued. View the product page for possible alternatives. |
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Description
Description: The HK5.3 monoclonal antibody reacts with mouse B7RP-1, also known as B7h, B7-H2, GL50 and ICOS Ligand. B7RP-1, a member of the B7 family, has a predicted molecular weight of ∽40 kDa and belongs to the Ig superfamily. Mouse B7RP-1 is expressed by antigen presenting cells including B cells, monocytes/macrophages and dendritic cells. B7RP-1 binds to the ICOS molecule (AILIM, CRP-1) expressed by activated T cells. The interaction of ICOS/B7RP-1 plays an important role in the T cell costimulation pathway. Applications Reported: The HK5.3 antibody has been reported for use in flow cytometric analysis. HK5.3 is not recommended for use in immunohistochemical staining. Applications Tested: The HK5.3 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filtration: 0.2 μm post-manufacturing filtered.
Inducible co-stimulator ligand (ICOSL) is a specific ligand on antigen-presenting cells and cells of the peripheral tissue that binds to the inducible co-stimulator receptor (ICOS). ICOS belongs to the CD28/CD152 receptor family that regulates T-cell activation and function. ICOSL is expressed on monocytes, dendritic cells and B cells and can be induced by inflammatory stimuli in peripheral tissue. Binding to ICOSL delivers a co-stimulatory signal for T cell proliferation and cytokine secretion.Specifications
CD275 (B7-H2) | |
0.5 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
Q9JHJ8 | |
Icosl | |
Primary | |
4° C, store in dark, DO NOT FREEZE! | |
Icosl |
HK5.3 | |
Flow Cytometry | |
Biotin | |
Rat | |
Mouse | |
50723 | |
IgG2a κ | |
Affinity chromatography | |
Antibody |
For Research Use Only.