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CD275 (B7-H2) Rat anti-Mouse, Biotin, Clone: HK5.3, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 13-5985-82

Additional Details : Weight : 0.25000kg

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Product Code. 15239979

  • 1926.00 SEK / 100µg

Estimated Shipment: 27-07-2021

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Description

Description

Description: The HK5.3 monoclonal antibody reacts with mouse B7RP-1, also known as B7h, B7-H2, GL50 and ICOS Ligand. B7RP-1, a member of the B7 family, has a predicted molecular weight of ∽40 kDa and belongs to the Ig superfamily. Mouse B7RP-1 is expressed by antigen presenting cells including B cells, monocytes/macrophages and dendritic cells. B7RP-1 binds to the ICOS molecule (AILIM, CRP-1) expressed by activated T cells. The interaction of ICOS/B7RP-1 plays an important role in the T cell costimulation pathway. Applications Reported: The HK5.3 antibody has been reported for use in flow cytometric analysis. HK5.3 is not recommended for use in immunohistochemical staining. Applications Tested: The HK5.3 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filtration: 0.2 μm post-manufacturing filtered.

Inducible co-stimulator ligand (ICOSL) is a specific ligand on antigen-presenting cells and cells of the peripheral tissue that binds to the inducible co-stimulator receptor (ICOS). ICOS belongs to the CD28/CD152 receptor family that regulates T-cell activation and function. ICOSL is expressed on monocytes, dendritic cells and B cells and can be induced by inflammatory stimuli in peripheral tissue. Binding to ICOSL delivers a co-stimulatory signal for T cell proliferation and cytokine secretion.
Specifications

Specifications

CD275 (B7-H2)
Monoclonal
0.5 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
Q9JHJ8
B7-H2, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, KIAA0653, LICOS, ICOS Ligand
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry
HK5.3
Biotin
Icosl
Liquid
Icosl
IgG2a, kappa
100 μg
4° C, store in dark, DO NOT FREEZE!
Primary
50723
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