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CD279 (PD-1) Monoclonal Antibody (EH12.2H7), APC, Invitrogen™
Mouse Monoclonal Antibody
Brand: Invitrogen MA538701
Additional Details : Weight : 0.01000kg
Description
Do not use after expiration date stamped on vial label.
Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "e;danger signals"e; such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.Specifications
CD279 (PD-1) | |
Monoclonal | |
APC | |
Pdcd1 | |
CD279; EGK_05005; hPD1; hPD-1; hPD-l; hSLE1; Ly101; mPD-1; PD1; PD-1; Pdc1; Pdcd1; programmed cell death 1; programmed cell death 1 protein; programmed cell death protein 1; programmed cell death protein 1-like; programmed death 1; Protein PD1; protein PD-1; sCD279; SLEB2; soluble CD279; systemic lupus erythematosus susceptibility 2 | |
Mouse | |
Size-exclusion chromatography | |
RUO | |
100400173, 101044440, 5133 | |
4° C, store in dark, DO NOT FREEZE! | |
Liquid |
Flow Cytometry | |
EH12.2H7 | |
PBS with 0.2% BSA and 15mM sodium azide; pH 7.4 | |
Q15116 | |
Pdcd1 | |
recombinant human CD279 | |
100 Tests | |
Primary | |
Human, Non-human Primate | |
Antibody | |
IgG1 κ |