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CD28 Syrian Hamster anti-Mouse, Clone: 37.51, eBioscience™

Syrian Hamster Monoclonal Antibody

418.00 SEK - 3655.00 SEK

Specifications

Antigen CD28
Clone 37.51
Target Species Mouse
Conjugate Unconjugated
Isotype IgG
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Products 4
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15296877
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Affymetrix eBioscience
14-0281-81
50 μg
418.00 SEK
50µg
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15206887
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Affymetrix eBioscience
14-0281-82
100 μg
844.00 SEK
100µg
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15216887
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Affymetrix eBioscience
14-0281-85
500 μg
1914.00 SEK
500µg
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15226887
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Affymetrix eBioscience
14-0281-86
1 mg
3655.00 SEK
1mg
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Description

Description

CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. CD28 is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes. Moreover, CD28 is the critical T cell costimulatory receptor that provides the cell the important second activation signal by binding CD80 and CD86 which are expressed by antigen presenting cells. In addition to its co-stimulation role, CD28 functions by preventing T cells from entering an anergic-hyporesponsive state or from undergoing premature apoptotic cell death. In murine peripheral lymphoid organs and in the blood, all CD4+ and CD8+ T cells express CD28. In the thymus, CD28 expression is highest on immature CD3-, CD8+ and CD4+8+ cells, and on CD4-8- cells that express alpha/beta and gamma/delta TCR. The level of CD28 on mature CD4+ and CD8+ alpha/beta TCR+ thymocytes is two- to fourfold lower than on the immature cells. Diseases associated with CD28 dysfunction include mycosis fungiodes and Sezary’s Disease.
Specifications

Specifications

CD28
Mouse
IgG
Monoclonal
Liquid
Antibody
4° C
37.51
Unconjugated
Flow Cytometry, Functional Assay, Immunohistochemistry, Immunoprecipitation
Primary
Monoclonal
PBS with 0.09% sodium azide; pH 7.2
RUO
SDS

For Research Use Only.