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CD28 Syrian Hamster anti-Mouse, Clone: 37.51.1, Invitrogen™

Syrian Hamster Monoclonal Antibody

Brand:  Invitrogen HM35005

Additional Details : Weight : 0.02000kg

Product Code. 10018692

  • 2785.00 SEK / Each


Estimated Shipment date
from Supplier 13-05-2019
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For Research Use Only. All usage must comply with product instructions.


Description

Description

CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. CD28 is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes. Moreover, CD28 is the critical T cell costimulatory receptor that provides the cell the important second activation signal by binding CD80 and CD86 which are expressed by antigen presenting cells. In addition to its co-stimulation role, CD28 functions by preventing T cells from entering an anergic-hyporesponsive state or from undergoing premature apoptotic cell death. In murine peripheral lymphoid organs and in the blood, all CD4+ and CD8+ T cells express CD28. In the thymus, CD28 expression is highest on immature CD3-, CD8+ and CD4+8+ cells, and on CD4-8- cells that express alpha/beta and gamma/delta TCR. The level of CD28 on mature CD4+ and CD8+ alpha/beta TCR+ thymocytes is two- to fourfold lower than on the immature cells. Diseases associated with CD28 dysfunction include mycosis fungiodes and Sezary’s Disease.
Specifications

Specifications

CD28, CD28
Monoclonal
Unconjugated
Cd28
Liquid
Cd28
Mouse T lymphoma EL-4 cells.
Purified
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry
37.51.1
PBS with 0.1% sodium azide
P31041
MGC138290, Tp44, CD28 antigen, T-cell-specific surface glycoprotein CD28
Syrian Hamster
IgG
2.5 mL
4° C
Primary
12487
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