missing translation for 'onlineSavingsMsg'
Learn More

CD28 Monoclonal Antibody (CD28.2), Biotin, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

730.00 SEK - 1832.00 SEK

Specifications

Antigen CD28
Clone CD28.2
Concentration 0.5 mg/mL
Applications Flow Cytometry
Classification Monoclonal
View More Specs

Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15259519
View Documents Promotion Details
Affymetrix eBioscience
13-0289-82
100 μg
1832.00 SEK
100µg
View alternative products
Save Up to 
»
In Stock
to see stock.
Please to purchase this item. Need a web account? Register with us today!
15249519
View Documents Promotion Details
Affymetrix eBioscience
13-0289-80
25 μg This item is currently unavailable or has been discontinued.
View the product page for possible alternatives.
N/A View alternative products
Save Up to 
»
Description

Description

Description: The CD28.2 monoclonal antibody reacts with the human CD28 molecule, a 44 kDa homodimer expressed by thymocytes, mature T cells and plasma cells. CD28 is a ligand for CD80 (B7-1) and CD86 (B7-2) and is a potent co-stimulator of T cells. Signaling through CD28 augments IL-2 and IL-2 receptor expression as well as cytotoxicity of CD3-activated T cells. Applications Reported: The CD28.2 antibody has been reported for use in flow cytometric analysis. Applications Tested: The CD28.2 antibody has been tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at less than or equal to 1 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filtration: 0.2 μm post-manufacturing filtered.

CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. CD28 is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes. Moreover, CD28 is the critical T cell costimulatory receptor that provides the cell the important second activation signal by binding CD80 and CD86 which are expressed by antigen presenting cells. In addition to its co-stimulation role, CD28 functions by preventing T cells from entering an anergic-hyporesponsive state or from undergoing premature apoptotic cell death. In murine peripheral lymphoid organs and in the blood, all CD4+ and CD8+ T cells express CD28. In the thymus, CD28 expression is highest on immature CD3-, CD8+ and CD4+8+ cells, and on CD4-8- cells that express alpha/beta and gamma/delta TCR. The level of CD28 on mature CD4+ and CD8+ alpha/beta TCR+ thymocytes is two- to fourfold lower than on the immature cells. Diseases associated with CD28 dysfunction include mycosis fungiodes and Sezary's Disease.
Specifications

Specifications

CD28
0.5 mg/mL
Monoclonal
Liquid
RUO
P10747
IgG1 κ
Affinity chromatography
Antibody
CD28.2
Flow Cytometry
Biotin
Mouse
Human
940
Primary
4° C, store in dark, DO NOT FREEZE!
Videos
SDS
Documents

Documents

Product Certifications

For Research Use Only.