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CD28 Mouse anti-Human, Clone: CD28.2, eBioscience™

Mouse Monoclonal Antibody

418.00 SEK - 844.00 SEK

Specifications

Antigen CD28
Clone CD28.2
Target Species Human
Conjugate Unconjugated
Isotype IgG1, kappa
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15236887
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Affymetrix eBioscience
14-0289-80
25 μg
418.00 SEK
25µg
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Estimated Shipment
15-01-2021
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15246887
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Affymetrix eBioscience
14-0289-82
100 μg
844.00 SEK
100µg
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In stock, ready to ship: 9
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Description

Description

CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. CD28 is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes. Moreover, CD28 is the critical T cell costimulatory receptor that provides the cell the important second activation signal by binding CD80 and CD86 which are expressed by antigen presenting cells. In addition to its co-stimulation role, CD28 functions by preventing T cells from entering an anergic-hyporesponsive state or from undergoing premature apoptotic cell death. In murine peripheral lymphoid organs and in the blood, all CD4+ and CD8+ T cells express CD28. In the thymus, CD28 expression is highest on immature CD3-, CD8+ and CD4+8+ cells, and on CD4-8- cells that express alpha/beta and gamma/delta TCR. The level of CD28 on mature CD4+ and CD8+ alpha/beta TCR+ thymocytes is two- to fourfold lower than on the immature cells. Diseases associated with CD28 dysfunction include mycosis fungiodes and Sezary’s Disease.
Specifications

Specifications

CD28
Human
IgG1, kappa
Monoclonal
Liquid
Antibody
4° C
CD28.2
Unconjugated
Flow Cytometry, Functional Assay, Immunohistochemistry, Immunoprecipitation
Primary
Monoclonal
PBS with 0.09% sodium azide; pH 7.2
RUO
SDS

For Research Use Only.