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CD29 (Integrin beta 1), FITC, clone: TS2/16, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 11-0299-41

Additional Details : Weight : 0.23750kg

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Product Code. 15506376

  • 690.00 SEK / 25 tests


EU Stock 3
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Description

Description

CD29 (beta1 integrin subunit, GPIIa) forms non-covalently linked heterodimers with at least 6 different alpha chains (alpha1-alpha6, CD49a-f) determining the binding properties of beta1 (VLA) integrins. These integrins mediate cell adhesion to collagen, fibronectin, laminin and other extracellular matrix (ECM) components. This interaction hinders cell death, whereas disruption of anchorage to ECM leads to apoptosis. Decreased expression of most beta1 integrins correlates with acquiring multidrug resistance of tumour cells during selection in presence of antitumour drug. In platelets, translocation of intracellular pool of beta1 integrins to the plasma membrane following thrombin stimulation. These integrins are also up-regulated in leukocytes during emigration and extravascular migration and appear to be critically involved in regulating the immune cell trafficking from blood to tissue, as well as in regulating tissue damage and disease symptoms related to inflammatory bowel disease. Through a beta1 integrin-dependent mechanism, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle in response to IL-1beta.
Specifications

Specifications

CD29 (Integrin beta 1)
Monoclonal
5 μL/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
P05556
FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB, ITGB1, ITBG1D
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
TS2/16
FITC
ITGB1
Liquid
ITGB1
IgG1, kappa
25 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
3688
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